I’ve only dabbled unfortunately as a proper sterile lab environment is needed, I’ve done tissue culturing for orchids and am definitely going to have a look at it for weed as soon as I can get myself set up.
It’s just this technique of ‘wide crossing’ is something I’ve read about which is basically what you guys are doing with the hops. If the hop pollen is causing the seed to form and then abort then it may be that this technique is possible.
Of course then what is required is a protocol of hormones etc to culture the undeveloped embryos to differentiate and grow, and also a mutagen like colchicine to duplicate the chromosomes and then bam, a plant with every chromosome identical and an IBL that will breed true.
Here is an article on the process: