I am totally anti-vaccine and I let them give me the tetanus shot!
Never done outdoor pollination but indoors I leave the seeds in the buds till it's dried out completely. Sometimes the calyxes dry up and they start falling out, I wouldn't be afraid to take those out.
I think they germinate better after a month or two of dry storage. That's good for weak seeds but if they're strong and healthy I think most will pop right away.