“Breath” strains are heavy hitters, tend to be great evening smokes & tend not to induce anxiety.
Hindu Kush autoflower; to date, this is the ABSOLUTE BEST effect I’ve had from smoking. The one i grew was a Seedsman freebie but I’m almost certain it was sourced from Sensi Seeds. Fantastic head & body stone, zero anxiety from this one.
Wow thank you fam for all of your suggestions 
We got a lot of new ideas to try out. What I’ve discovered so far is that cultivars with a lot of Terpinolene seems to be a big no no… Which happens to be what my brain want. 
A lot of you seem to think that GDP is a good idea and I got some F2 seeds from Ken I’ll pop right away for her.
We are always open for more suggestions from you guys 
Pz 
In terms of newish strains widely available peanut butter breath (like rookie buds said) seems to produce no anxiety it does have a long half life though.
I’ve tried so many wedding cake hybrids I’m nearly sick of it but the zskittles one was the clearest sativa leaner buzz I’ve had in a long time. I wonder if zskittles could provide a gentle daytime but someone who’s worked with it would know more.
Used to just floor my THC and terpenes, now I try to look for a complex blend instead. Myrcene over 10% didn’t go well for me (Kush Mountains), but that’s just my conditions. Really been trying to utilize a wider terpene profile rather than just more, more, more. I was going through some heavy abuse at the time, so a ticket out of reality was a Godsend.
I got Au-ADHD, Generalized Anxiety Disorder, some undiagnosed CPTSD symptoms, undiagnosed Bipolar, the list goes on. Aspergers proves time and time again it can make my brain chemistry mimic almost any mental baggage.
Tl;dr - Do-Si-Do works good for a daytime for me, little to no paranoia in my experience. Kush Mountains made me a mess for a few days, but I slept like a rock. White x Silver Haze was also a really great choice. Smoked well, kept you moving without being jumpy.
My opinion may be different than others. Thc has been proven to trigger anxiety so I’m not sure how pure thca plays out well. I had pretty bad issues with weed triggering anxiety attacks that actually hospitalized me with 200+bpm heart rates. Also irregular heart beats. Then comes depersonalization. Where you no longer control your thoughts and it just goes downhill from there. Honestly no benzo. I got put on Lexapro 20 mg. And biggest thing is doing something while I’m high. If I roost myself up n just sit there doing nothing that’s when my brain goes crazy. Hasn’t happened in about a year now. If I feel off I get to doing something. Give the brain tasks so it don’t wander. Just my experience.
I’ll be honest too. Thought about this a bit this morning and what helped me the most wasn’t cannabis. At the risk of sounding like a douche, I feel like I gotta tell you that my biggest problem was being in an abusive environment. Walking on eggshells for 25 years straight messes a person up. I didn’t even start healing until I was well away from that environment for months on end. Cannabis can hold your hand and make that part a bit easier, but if you feel like someone or something (could be a job, a coworker, an area you revisit with traumatic memories) is triggering it, it is. Don’t ignore your instincts. They’re usually right even if they aren’t kind how they break it all down for you.
Just had that thought that it’s possible you’re in the same boat I was in, so I had to comment on it. If you don’t have anything going on like that, I’d just continue tuning in your strain requirements.
There are a bunch of great suggestions here for strains but just in my personal experience, strains tends to differ slightly run to run. I’ve kept plants for longer periods of time and depending on wether it is grown in summer or winter, how long she is run for, what specific nutes I’m running etc etc, I can get different results from the same strain, even from clones. I know some people have really dialled in grow spaces that never change temp or humidity or take great notes and can recreate exact runs over again but I’m not on those people so this is just what I’ve seen.
My recommendation would be 1:1 THC:CBD strains. I have found the CBD helps soothe a lot of my anxiety. My main concern at first was that they wouldn’t be very potent but I have grown very potent weed that was 1:1 that got me really high but never anxious, even in socially taxing situations.
1:1 with high ratios? What strain was that? I might have to give it a spin myself. Smoked some low 1:1, excellent body buzz but it gives me the ruderalis headache.
Sorry I don’t have much specific information on strains. I was just pointing out that I believed the high would be crap for 1:1 strains but I was wrong. I ran a mephisto auto 1:1 a buddy breed that was a good strong high but with the CBD also no anxiety. I could smoke a pile of this and get pulled over by the cops and be chill. It was great.
A lot of people on OG are right into the THC/CBD strains so I’m sure someone will have some great recommendations 
"You are freaking out. Man."
Hands officer Uno Reverse In Green
To the OP,
Best wishes for finding relief for your wife.
I’m seeking on that same path. Plant Prozak.
A dear friend, who is going through a savage harsh time, well the past 5 years now, due to her son perishing in a fire related death.
A really wonderful young man. My son, and her son played soccer together as kids, sleep overs, family outings…
I do not think, she will last on Earth much longer, she is REALLY trying to work through it.
I’m still early into my project, but I’m working some Celia Bx1, TurnSpit Genetics, that Syrup, made, using OldTimer1 Smile project, as he was seeking to capture a Prozack type of plant.
I’m then going to focus on putting them in capsules, for her to use, we are then, going to pack up some powdered mushroom for micro dosing.
I made her some knock out oil, in a hobby syringe, for when she is losing her grip, but I fear if that stops giving her the knock out effect, she make seek, the final knock out.
I know, she trying to keep on treading water, so to speak, I just want her to find some peace, and stay here on Earth.
All we can do is keep trying.
webe
That’s insanely intense of a story. I haven’t heard of anyone in that bad of a situation in a long long time. If I were in your shoes (I’m not), I’d be looking bigger. If you’re already sure you’re going to lose her, I trust that. DMT, Cane Toad, Peyote, Ketamine these are things I really feel you all should consider (under strict professional supervision of course). If she doesn’t get guidance to the other side soon, I think you’re right. She’s going and staying there. Her Son went up in flames, I won’t sugar-coat it. That’s the most horrible thing I’ve been hit with in a long loooong time. Contact Shamans/Holy People/Trauma Specialists in your area, Immediately. If you can’t find anybody, I will help you look for someone that can offer assistance over the internet. (DMs are absolutely fine)
That hit me really hard in the empathy, so sorry if I got a little out of pocket. 
Damn, that’s heavy. There is no cannabis in the world that will fix it for her. She needs to be in trauma therapy asap. I’ve been there when my best friend and considered closest family passed away.
Pz
She is a dear soul. Has been working with a few different doctors. The meds they prescribe to her, makes her more fragile, and she hates that. She is a fighter!
She is really fighting for level, she meditates, changed up her diet, hunts for psychological help, that does not pump her with chemicals, as that, seems to just fuel her unsettled mind.
She is a very lite cannabis user, teas, edibles, far more than puffing it.
The blob of oil, is for when, she can not calm her mind, she said, I want a knock out item.
Afterwards, her knock out times seems to follow with a couple of days of calm sailing for her.
She also has a daughter, and holds on dearly, for her, as she also has lingering issues from her brothers passing. She is just zoning out on the prescribed stuff. But it is now the 5th year, so she has to find a better path. The daughter is not a cannabis user.
If we had not spent 75-80 years demonizing this plant, how far forward could we be, with some mind strengthening attributes? Sorry to get all political, I do apologize.
I only see forward for her. Her and I always find a way, to giggle at something.
She has found great peace in donating time to an animal rescue foundation, and has volunteered for over 3 years now. Lots of exercise, lots of walks, bicycling, running on the local Trails .
The holidays are her worst times, of course.
I also set them up a small garden, 4 years ago now, and she is running it in a perpetual cycle mode.
So she is doing the work, and every few weeks I see her, I THINK, her spark is coming back.
But every once in while, I can see that fucking demon, trying to enslave her, to torture her more so. I just feel helpless at times, and other times, I just read trying to scour information to help her fight back.
I’m going to find something for her and her family, damn it!
I just do not want to run out of time.
There it is, you have my interest. I’d suggest to make a thread for this particular situation specifically. A collaborative effort on this specific case is a tool you need in your arsenal. I’m sure dozens of people would find some empathy and drop in to offer suggestions, support, or perhaps even dedicate seeds or cuttings to the cause.
Good luck, from the bottom of my heart. As long as you continue to post about this, I’m going to continue to keep an eye on it. When I have the ability to offer more than emotional support and time doing research- You’ll know.
Read through most. Med user here with CPTSD/PTSD and the anxiety/sleep terrors/panic attacks/etc. . .pretty much all the classic stuff hits hard. SNRI is my main med and it’s been the best compared to SSRI. Weed def is a mood stabilizer, sleep aid, motivation giver.
Daytime regulars -
Moby Dick
GG4
BOG Sour Bub/Bub
Diesels
Sleep/chill out
Skywalker
Chems
Diesels
9lb hammer
Master and Triangle Kush
Other heavy deep earth kushes/strains
Motivation
Hazes
Durbin lineage
Silver Haze specific (hunting. Might have it from SShashplant)
Western hemisphere sativa’s
RSO is by far one of the best forms I’ve had. Need to make my own. Diesel on there twice cause it can go either way honestly.
Sour Bub seems to be on a lot of PTSD lists. I still need to get my hands on some. Luckily getting in on the Bluetooth and Moon Rocks co-ops in time but not the BOG Kush. Have gotten it in gorilla bubble from what I can tell.
9lb hammer I can’t suggest enough, along with GG4. 9lb and GG4 as RSO are killer. Little rice size and you’re good. I actually smoke less. Been making tincture and it’s almost as good.
Stuff I’m trying next is from OG’ers. Some sour Bub crosses and 88g13hp.
Oh and things that I need to go back in lineage or crosses for is Interstellar/Deathstar/Starfighter.
Things that fuck me up is mostly Amnesia Haze stuff. I get suuuuuper head high and it’s nice.
For me a 1:1 THCA:CBDA tincture has stopped panic attacs in their tracks.
Great response…I concur
I go through the the same anxiety issues and found experimentation led me to strains like jack here, land race varieties tend to not give me panic. And I’ll take a super small toke and wait to see how I feel…instead of taking a huge dab and wonder what will happen…and I do it alone so no other vibes effect anything
Guinea pig yourself. That is how I figured out what works and doesn’t work.