@Tonygreen great points here about excluding the Y chromosome to get a more homozygous line at a quicker rate. You are right on about the math (Weinberg Law).
The concept of excluding the Y chromosome I think totally aligns with manipulating gene frequencies to obtain a true breed strain. I’ve also heard that back crossing is effective to stabilize the breed with the dominant traits you are trying to lock in.
Either way, inbreeding / selfing sounds to be the effective method for adapting a strain from a heterozygous gene pool, to a homozygous gene pool. There are still some elements that we can’t control (gene interaction, gene linkage, sex linkage, etc.).
Variate, Isolate, Intermate, Evaluate, Multiplate, and Disseminate.
Edit - Wanted to include the attached pic. Not sure where I found it to give proper credit.
