There are different formulations for permanent markers, including Sharpie pens. Some are considered nontoxic and safe for use on skin. Others contain toxic solvents that may cause organ damage from inhalation, ingestion, or skin absorption.
Sharpie Fine Point Markers are the safest pens to use on skin. Even with these pens, it’s a good idea to avoid writing on the lips or near the eyes.
King Size Sharpie, Magnum Sharpie, and Touch-Up Sharpie contain xylene, which is neurotoxic and may damage other organs. Xylene poses a risk via inhalation, ingestion, and absorption across skin and mucous membranes. Writing on skin with these markers isn’t recommended.
There’s also different kinds of sharpies, toluene, alcohol, ethanol or isopropanol, ethylene glycol monobutyl, propanol, butanol, and diacetone. resin or polymer is added as a “binder” that promotes adhesion. Permchrome ink has the alcohol but not glycol ether.