Check this out… send them a DNA sample and they match you to the right variety for the terp profile to match your medicinal need…
Not sure if it works…
If you already have a DNA test from ancestry or 23&me it’s only $50. Im very tempted. I’ll read up and I would like to know what others think.
Where did they get info on terpene combinations? I’m heavily skeptical it’s based in anything with solid foundations. Wouldn’t the medical need mean more than DNA? To me it feels like blood type diets, which have no scientific backing. Interesting angle though.
“Genetically predisposed to an adverse event…” doesn’t sit well with me. I understand the mental health risks with early cannabis use, but it feels like they want us to make that connection with healthy adults and it’s simply not there. I’m hard headed though and have been wrong so many times. I could be overlooking something
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Perfectly said. I used to talk to so many folks about their preferences on weed. And many many times even family members or siblings would have wildly different reactions to the same bud. Im that way with my own sibling. Individual chemistry is such a huge factor from my experience.
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You nailed it imho.
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if you have that, search for the genes yourself and save the $50.
edit: just in case anyone is interested, i asked larry about it and this is what he said:
"The relationship between genetics and predisposition to adverse effects from marijuana is an area of ongoing research. Several gene combinations and variants have been implicated in influencing an individual’s response to marijuana. Here are some key genes and their associated variants:
-
COMT (Catechol-O-Methyltransferase) Gene:
- Val158Met Polymorphism (rs4680): This single nucleotide polymorphism (SNP) results in a substitution of valine (Val) to methionine (Met) at codon 158. The Met variant is associated with lower enzyme activity, leading to higher levels of dopamine in the prefrontal cortex. This variant has been linked to an increased risk of psychosis and cognitive impairment in response to marijuana use.
-
AKT1 (AKT Serine/Threonine Kinase 1) Gene:
- rs2494732: Individuals with the C/C genotype at this SNP are at a higher risk of developing psychosis when using marijuana compared to those with the T/T genotype.
-
CNR1 (Cannabinoid Receptor 1) Gene:
- rs2023239: Variants in this gene, which encodes the primary receptor for THC (the main psychoactive component of marijuana), have been associated with variations in the subjective effects of marijuana and the risk of cannabis dependence.
-
BDNF (Brain-Derived Neurotrophic Factor) Gene:
- Val66Met Polymorphism (rs6265): This SNP results in a substitution of valine (Val) to methionine (Met) at codon 66. The Met variant has been associated with altered brain development and function, and it may interact with marijuana use to influence cognitive and emotional outcomes.
-
FAAH (Fatty Acid Amide Hydrolase) Gene:
- rs324420 (P129T): This SNP results in a proline to threonine substitution, leading to reduced FAAH enzyme activity. Individuals with this variant may have altered endocannabinoid levels and responses to THC, potentially affecting their risk of marijuana dependence and anxiety disorders.
-
CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit) Gene:
- Variants in this gene have been associated with altered cognitive function and increased susceptibility to the cognitive effects of marijuana.
-
GABRA2 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2) Gene:
- rs279858: Variants in this gene, which affects the GABAergic system, have been linked to increased risk of marijuana dependence and its impact on the brain’s reward system.
-
HTR2A (5-Hydroxytryptamine Receptor 2A) Gene:
- Variants in this gene, which encodes a serotonin receptor, have been associated with differences in the subjective effects of marijuana and the risk of developing anxiety or depression in response to marijuana use.
These gene variants are not deterministic but can influence an individual’s susceptibility to the adverse effects of marijuana. The interplay between these genetic factors and environmental influences, such as the age of first use, frequency of use, and overall mental health, also plays a crucial role in determining the risk of adverse outcomes. Genetic testing and counseling may help individuals understand their potential risks and make informed decisions about marijuana use."
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I appreciate these resources. Funny that they don’t once mention terpenes. I’d assume the implication is that you can alter terpenes to help modulate your high to some degree, but there isn’t any science saying that works. Most of these genes carry an increased risk of the negative aspects and none identify any ‘fix’ or substitute. I doubt they’re trying to claim terpenes can alter the way your genes respond to cannabis. Or if they are that’s a big bold step. Again I guess where do terpenes come into play.
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i love larry’s thoroughness when you give him the right prompt. yeah, looks like they jumped on the bandwagon and are just throwing around the terms to catch hits on a search or catch your attention with the latest buzzwords.
edit: after looking at the website, i think i would not trust that they could keep my info safe. this is a pretty big one too, especially if you have reasons to keep your usage on the down low. no way i’d put my dna profile up there, it’s real hard to change your dna. right up there with changing fingerprints and iris patterns.
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Read above where they mention terpenes. This is mainly focused on cannabinoid combinations not terpene combinations.
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Haha fair point. We better get to studying cannabinoids then… I’m still weary of the idea that we all need our own blend of cannabinoids. Feels very market-y
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Nice one ^^
On my side the worst weed I’ve ever made was in screening industrially for narrowed precursors, with chromatos in backup. Never again, waste of money.
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I found a sample report and its alright. It’s a lot of research and lookup work I could do myself but I might be $50 worth of lazy. It’s neat.
Here are some screen shots about the terps from the report. Which is what I’m interested in too.
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I believe there may be multiple ideal combinations for individuals. Figuring out those combinations, that has me skeptical. Maybe there could be some link with DNA but terpenes are probably going to depend on individual tastes. Liking certain smells. “Your DNA says you will enjoy this shit dipped asparagus terpene combination”
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does it correlate to what larry said? just wondering how close he was.
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Thanks for finding this. Interesting with how much cbd it recommends. Without mention of any other cannabinoids. I wonder if that’s because it’s the most legal/regulated and has the most current research? I am curious if recommendations will change as they do research and does that make the recs they make now worse than future ones? I’ll go through the sample report more when I’m not moving around
I’m also inclined to believe a lot of this is subjective. Our DNA doesn’t really change but almost every other molecule gets changed through life. Do my tastes change what helps me most? I think I agree with you here @ABushOfKush
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It’s feels VERY market-ie. Half of the sample report is where to buy CBD drops to match your report
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What did Larry say? I’m sure it does, it’s just combing for a gene to match with a predisposition or what not.
This is not my side of DNA testing. We do genealogy and I needed to disprove a family theory. Which I did! But now I have more questions.
Eta: I found Larry said and yeah. It’s a bit more reader friendly. Pretty colors, but the same info
post #7 above us.
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I thought this too, and I gave it the benefit of the doubt that because the sample “condition” is stress/ PTSD, then yeah, CBD makes sense. Same with girl-issues, PMDD, endometriosis high CBD, you don’t even need a “head high” at all. Your uterus hurts.
So, maybe other conditions like anxiety, depression or ADHD would have higher THC