This is an interesting read that kinda correlates what you’re saying.
Genomic studies of several new synthase variants have been recently carried out (Weiblen et al. 2015; Grassa et al. 2018; Laverty et al. 2019; Gao et al. 2020). Initially, CBDAS and THCAS were identified as co-dominant alleles at a single locus where BT/BT and BD/BD homozygous plants are THC and CBD dominant, respectively. However, recent advances in genomic studies have suggested the involvement of multiple linked loci harboring alleles at different loci. Weiblen et al. proposed this observation based on several factors such as the presence of diverse THCA and CBDA synthase sequences in test samples, expression pattern, and loci position on chromosome map (Weiblen et al. 2015). Onofri et al. suggested that THCA/CBDA variation is due to sequence variations at the B T and (or) B D loci (Onofri et al. 2015). However, Grassa et al. reports that divergence at the CBDAS loci is mainly responsible for determining the THCA:CBDA ratio of cultivars, resulting in cannabinoid profile differences between marijuana and hemp (Grassa et al. 2018). Interestingly, variation in gene copy number of THCAS and CBDAS has also contributed to varied cannabinoid content in cultivars and is responsible for phytochemical diversity, which helps with plant adaptation (Vergara et al. 2019).
