Very cool @Cactus
I don’t totally understand it all but it sounds like the shape shifter gene… 
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Yea,
Yea starting to read up more on it and it reminds me of the “Thing” with all the stuff it is doing. Not surprised, nature has been messing with all this stuff for millions of years so why not.
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@mithridate , did I see you say some where 
lol , that the only way to get a double recessive , is by breeding kids , so no bx or P gens? Thanks oh and I’m out of likes btw
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genetics0729.pdf (747.9 KB)
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Is anyone familiar with the shikimate pathway ?
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Or, did glyphosate kill skunk weed ?
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The last time I had real skunk weed it was 2003/4 I lived in Daytona Beach Florida. Knew this guy he was big time n had a friend with a grow house In Holly hill next city over he took me there i sat in the car windows down he ran inside came back out by the time he made it 10 feet from the car the stank hit my nose, we smoked a blunt and I shit you not I was high as a giraffes puss for the rest of the day talking 6 to 8 hours eyes red stoned to the bone. Was my first and last experience with true skunk weed. I feel it’s still out there waiting in a seed to be found again if someone isn’t already hoarding it lol
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GMO’s seem to be a real pain in the ass for everyone since the pathway seems to be getting axed at every turn and we weren’t modified to handle the new combos that are coming out that have altered this pathway that we have evolved out and rely on plants with this functionality to keep us healthy.
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It does seem to be responsible for many processes touching plant defenses, gut microbiome health and nutritive value of foods…
The glyphosate pollution/ soil accumulation snowball started to really roll around the mid 80s to mid 90s, exactly the same period where skunk disappeared off the earth. Foolish observation, possibly 
Got me wondering how this pathway affect aromas and flavor of plants/fruits/flowers.
Quote
The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites. All pathway intermediates can also be considered branch point compounds that may serve as substrates for other metabolic pathways.
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Could very well be hiding in 30 years old seeds 
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Found this, thought this would be interesting if anyone has time to look at it. Two parts and packed full of good stuff!
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This kinda seems like natures own crisper type thing. Thats if I’m understanding properly.
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Yea where do you think we got the idea for CRISPR! Hehe natures already figured it out 
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Linkage:
This is something that we see and plays into so many aspects of breeding and how it effects selection. This is the process that makes breeding fun. I wonder if finding a keeper falls into cross-over.
Transgressive segregation
Furthermore, there are several meioses in the F2 and during the inbreeding stage, with the result that the amount of-recombination is increased fourfold; this is now called map expansion and is very advantageous for mapping closely linked loci.
RIL LINES.pdf (733.3 KB)
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Hey man, I’m curious as to what you think makes the skunk smell so hard to pin down? It shows up in open pollination but so far targeted matings don’t enhance the probability. I’m sure selfing could at least help sort them. It’s giving me thh high deja vu…
Too complex a trait ?
Maybe you don’t care for it, just wondering 
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Well very intriguing. I think we have selected against it so much that it has become even harder to find. I wonder if we are looking at this. By selecting against it so much in past we have closed the distance so the loci are like 2% or tightly linked loci.
Bottom row where it states they are tightly linked. I wonder if I had a smelly male and crossed to a female and lost it then? I wonder if I took that just say recessive male and selfed it then what. Just spit balling for these are characteristics that could be linked or a product of epistatic/hypostatic processes.
Do we dare talk about TEs
Eric Lander. this guy is very interesting
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Interesting take, although I hate the "it was bred out " perspective I guess some of that is inevitable…
Transposable elements now? I’m not very fluent in those man
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Well let’s look at it this way, maybe the skunky smell might be like say finding a 5% winner are all tied to cross-over? Thus if the skunky type comes out during an open pollination then why is that not a possibility. That would support what has been posted and thus you might be onto something @Mithridate 
.
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@Mithridate Have you heard about that terpenes don’t really play in the role of skunk smell? I wonder then if there is some chemical in the Trichomes that when struck by high amounts of ultraviolet light cause a chemical reaction to the structures that cause the skunk smell.
Maybe this is what happens and shares this with hops? When alpha acids break down from being hit by ultraviolet light they immediately react with the sulfur in the beer, hence producing a chemical compound known as 3-methyl-2-butene-1thiol (MBT). This compound is responsible for the skunky smell in the skunky beer. I am a home brewer so this I thought might be a parallel. What do hops and 
cannabis share in common?
Pic of my cascades
All yeast strains produce some amount of hydrogen sulfide during fermentation as a by-product of sulfate processing. Saccharomyces cerevisiae can produce up to 290 micrograms per liter of hydrogen sulfide in wine. The human threshold for detection is a very low 0.01 micrograms per liter.
Sam mentioned in last podcast that they isolated or know that the Southern tropical Indica’s when crossed with the Nothern Afghani/Pakistani types will be resistant to fungus mold yeasts types. So if your environment is dry then the yeast that like maybe a mycorrhiza type is in a symbiotic relationship as long as the environment is dry? When crossed with the tropicals the fungus is lost as well as the skunk smell. This finding a fungus friendly type and crossing it with fungus friendly types might be an option? Just throwing out some crazy ideas!
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Yes! Folklore mentions using 300-500mn supplemental uv light to bring out the skunky smell. Interestingly, dankwolf in his trials noticed some cuts/lines not known to be skunky turned skunky in the sun…
Many claim the old skunk was always grown outdoors (and taken long?)
Now if multiple lines can aquire a skunky twist, sort of a baseline, I wonder what made skunk the queen of stench. It’s almost as if some reaction is not takin place, or something is preventing the reaction to occur fully.
I tried to make sense of different pathways and reactions but blanked…
Wow, again the old skunk was known as a mold magnet, at least in more humid areas/years.
Seeing how lines were seeded year to year, could it be that malnutrition one year affected how some processes are expressed.
Boron guy claims malnutrition will ruin a line permanently. I think, as in the case with other living things, the effects of a poor diet on a single generation can be felt for up to 6 following ones, but will remain coded and potential can be retrieved.
Was it bred out? Inadvertently, quite possibly. Also why open pollination might pick up some remnants of health ?
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