Well I guess it depends on your concept of ruin… Ultimately if the goal is seeds nothing is lost, if things work out you will have plenty of more opportunities to grow out the offspring hundreds of times over. If it goes south, you will have 2 poisoned plants and the experience to hopefully do it differently next time.
I have no personal experience with selfing AUTOs although I have asked this question myself coming into my own Auto breeding project. The most common response I hear is that if you are selfing you will need to start spraying fairly early on. Auto males naturally will so signs of sex earlier than female autos by about a week. Typically strategy I have seen here with the many people reversing is to start spraying 3 weeks before planting another run of the same FEM seeds so that by the time the reversed plant is pushing pollen the other plants will be at the right stage of flower to accept pollen and produce seed to maturity by the time the plant has completely flowered and starts to autumn and die.
With straight-up one plant selfing, there is a risk of not getting the timing right and seeds not maturing in time although it seems pretty rare. I too will wait for more experienced folks to pipe in as I am interested in this as well.
Great selection you have there, wishing you all the luck seflishly as I would love some of your seed should you be willing to part with them when the pollen settles